Whether plasma low-density lipoprotein cholesterol advances arteriolosclerosis or not is unclear. An indication of the function of renal arterioles and glomerular capillaries is the estimated glomerular filtration rate. In order to speculate on the effect of plasma LDL-C on arteriolosclerosis, the relationship between e-GFR and plasma LDL-C was investigated in order to estimate the effect of plasma LDL-C on the function of renal arterioles and capillaries of glomeruli. Coronary heart disease risk factors health evaluation and promotion centre’s examinees were divided into four groups based on their e-GFR: the control group, Group 1, Group 2, and Group 3, from highest to lowest e-GFR, were compared in terms of blood pressure, plasma lipids, and fasting plasma glucose. There were 4602 and 2920 total male and female subjects in the study. When compared to the Control group, plasma LDL-C levels were significantly higher in Groups 2 and 3 for all male participants and in Groups 1, 2, and 3 for male participants over the age of 50.When compared to the Control group, plasma LDL-C levels were significantly higher in Groups 1, 2, and 3 for all female subjects and higher in Groups 2 and 3 for female subjects over the age of 50.Subjects of both sexes who were in their fifties had identical plasma levels of LDL-C at all ages. BMI and abdomen periphery were higher in male subjects with low e-GFR yet not in female subjects. When compared to the Control group, which included all subjects and those over 50 in both sexes, subjects in Groups 1, 2, and 3 did not have elevated blood pressure or fasting plasma glucose. We reasoned that the high plasma level of LDL-C was the significant gamble factor among coronary gamble variables to decrease GFR presumably due to hindering the capability of renal arterioles and vessels of glomeruli in subjects with ordinary kidney capability evaluated by urinalysis and plasma creatinine. Kidney capability is surveyed regularly by urinalysis and plasma levels of creatinine and urea nitrogen. As a recent indicator of kidney function, estimated glomerular filtration rate has been used-GFR is often low in subjects whose kidney function is found to be normal by urinalysis and plasma levels of creatinine and Unit is known that metabolic syndrome, hypertension, diabetes mellitus, and other coronary risk factors impair kidney function.

With Regards,
Sara Giselle
Associate Managing Editor
 Journal of Critical Care Obsestrics & Gynocology