Lead is lethal metal which can be used in different fields. Lead metal has a harmful influence on human care, it effect on all body systems. Lead nanoparticles (Pb NP) can be sensitized by different methods including chemical, physical, and biological methods. The furthermost inferior method is biological method owing to its ecofriendly, low cost, simple, not consume time, and not requisite luxurious tools. Pb NP entertainment as antimicrobial medications; this may perhaps in line for its capability to penetrate cell membrane of microbe, thus increase permeability of cell membrane, accumulation of Pb NP inside microbe. Once lead separated from Pb NP, it transfers in to respiratory system and bind with respiratory enzymes and deactivated them, leading to release free radicals, increase reactive oxygen species and cell destruction, so lead nanoparticles have a significant antimicrobial influence. Nanotechnology is a branch science which deals with producing and utilizing nano-sized particles that measure in nanometers. These nano-compounds are already having important proposal in different fields and in human care. There are different techniques in synthesis of these compounds, they may be a chemical, physical, and biological method which is anew, simple, rapid, and not cost strategy to synthesize metal nanoparticles utilizes biological tools such as bacteria, yeasts, fungi, and plants. The common of researchers prefer using biological methods in preparation of different metals nanoparticles, in this technique the various plants are used to extract different nanoparticles with different size. This technique is very cost effective, and can therefore be used as an economic and valuable alternative for the large-scale production of metal nanoparticles. Lead is extremely poisonous heavy metal. Lead metal affecting very nearly on all organ and system in the body. The major target for lead toxicity is the nervous system. Lead poisoning usually produced from consumption of food or water polluted with lead; not only but also may happen after unplanned ingestion of contaminated soil, dust, or lead-based paint. Bioremediation of lead by bacteria could be an effective measure to remove lead. Lead is used in metal field and in ceramics fabrication in different countries and so continues to be of concern to public health. Low concentration of Pb toxicity causes several metabolic, neurological and behavioral disorders. Many recent studies have indicated that even lower blood Pb levels are associated with impairment in psychological progress, diminished skeletal growth, and disturbances in cardiovascular function. The nervous system is the furthermost sensitive target of lead exposure. In line for to otherwise asymptomatic individuals may experience neurological effects from lead exposure, doctors must have a high index of suspicion for lead exposure, especially in the case of children

With Regards,
Sara Giselle
Associate Managing Editor
Journal of Medical Physics and Applied Scinces