Description

Cell signaling, which typically takes place at the interface between organisms or cells or between organisms or cells and abiotic materials, is an important phenomenon for monitoring the development of diseases. As a result, figuring out how to build the specific biomedical interfaces will help control the flow of information and produce better therapeutic outcomes for patients' benefit. Plasmas containing energetic and active species have been used to build a variety of interfaces over the past few decades to meet biomedical needs like the inactivation of bacteria, the regeneration of tissue, cancer treatment, and so on. This brief review aims to provide researchers with guidance on how to select the appropriate plasma and processing conditions to design and prepare interfaces with the optimal biological and related functions. It is based on the potent functions of plasma modified surfaces. After a brief introduction, plasma-activated interfaces, including direct plasma-cell interfaces and indirect plasma-material-cell interfaces, are described and categorized according to various criteria. Additionally, recent research on the application of plasma-activated interfaces is described.

Organisms and cells have a complicated system for carrying out particular tasks that involves a series of steps that are connected by signal transduction. The biological behavior particularly that which is associated with the onset of diseases, is regulated by signal communication, which typically takes place at the interfaces between the internal biological environment and external substances. Ion channels for calcium exchange are triggered, for instance, when there is an imbalance in blood glucose between the two sides of cell membranes. In point of fact, the majority of physiological processes associated with metabolism, apoptosis, and other activities of self-repair rely on signal transduction at the interfaces, and the right interfaces are essential to research into biological functions and biomaterials. Plasma science has been linked to nanotechnology and nanomaterials thanks to the recent growth of interdisciplinary research. Plasma's active species, for instance, can be introduced to biomaterial interfaces in orthopedic, dental, and vascular implant biosystems. Plasma physics and plasma medicine have also been the subject of in-depth research to better understand how interfaces control a variety of biochemical responses. The purpose of this brief review is to provide an overview of the most recent developments in plasma-activated interfaces and to explain how plasmas are used to create these interfaces.

Plasma is an electrically neutral system made up of electrons, ions, excited particles, and neutral particles. It is the fourth fundamental state of matter after solid, liquid, and gas. Plasmas exist on Earth in the form of lightning and aurora, in addition to being the primary state in extraterrestrial phenomena. Plasmas can be divided into thermal and non-thermal types based on temperature, as well as metal and non-metal types based on their constituents. Plasma-based processes are widely used in the commercial sector, particularly in the microelectronics and coatings industries, due to the high energy of the metastable active species in plasmas. It is now widely acknowledged that the combination of the components in the complex system contributes to the therapeutic effects, given plasma's cocktail peculiarity. 

Warm Regards,
Deepika.K
Journal Coordinator
British Biomedical Bulletin