Liver is the principal site for metabolism and excretion in body. The human liver metabolizes substances by various biochemical pathways including oxidation, reduction, hydration, condensation, hydrolysis, conjugation or isomerization. Disorder of any of the afore mentioned process may lead to liver cell injury, what we call as hepatotoxicity which in turn leads to many diseases. Such diseases are responsible for higher mortality rates worldwide. Hepatotoxicity can be due to medicines, chemicals, dietary disturbances or herb induced liver damage via hepatotoxins. A number of herbal and herbomineral preparations are available in the Ayurveda, the traditional Indian Medicine which have been investigated for their hepatoprotective potential to treat different types of liver disorders. The present review is focused on different herbal plants that have potential to cure the hepatotoxicity. The liver tolerates maximum insult in detoxifying the various toxins present in the food, drinks, drugs and environment. Many risk factors predispose an individual to hepatic drug injury such as pre-existing liver disease, aging, female sex, and genetics. Liver being a major site of metabolism plays a pivotal role in detoxification of various toxins ingested and or produced during absorption of the food material. The liver usually filter all the blood from the digestive tract, before passing it to the rest of the body to avoid entering toxins in the other body system. It utilizes different metabolic pathways for energy production, metabolism and reproduction to control almost all systems of the body. Liver also synthesizes many complement systems and proteins for supporting immune system. Therefore, healthy liver is key to healthy individual.

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With Regards,
Sara Giselle
Associate Managing Editor
Global  Journal of Digestive Diseases