The purpose was to study the clinical, pathophysiological and hemodynamic features of the course of chronic migraine. 82 patients with chronic migraine were studied, aged 12 to 47 years; the average age was 31,9±3,8 years. For comparison, 85 patients with simple migraine (migraine without aura) were selected, aged 14 to 42 years, and their average age was 29,2±2,6 years. The following analysis were carried out: clinical, neurological, electroencephalographic, and hemodynamic studies, the ID-migraine questionnaire, MIDAS scale (with the determination of migraine severity), EEG, and cerebral vascular ultrasound. Clinical and neurological, bioelectric and hemodynamic features of chronic migraines have been identified – prolonged migraine paroxysms, intense headaches, reduced performance, daily work activity lead to deterioration of the condition and form psychopathological manifestations, reduce the quality of life; EEG parameters can be objective indicators of the development of acute and chronic vascular complications, determining organic brain damage; migraine paroxysms are the background for the violation of the quality abilities of the cerebral vessels, and the frequency and duration of attacks change the normal physiology of the cerebral blood supply to the brain, being a predictor of acute and chronic brain ischemia.By studying the problem of migraine, we were convinced of the complexity of etiopathogenesis and the presence of various theories regarding the formation of its complicated forms. One of the theory is a biochemical one, which states the hypoactive cell membrane due to decreased level of serotonin in the blood, which cause pulsating headache. The predominance of migraine attacks in women says the opposite – changes in the level estrogens in plasma increases the content of serotonin.Summing up the complex pathophysiological concept, it is necessary to take into account that migraine is a significant disease for humanity, accompanied by serious complications such as disorders of the functioning of cerebral integrative vascular and neuronal mechanisms that lead to the interaction of the adaptive and antinociceptive systems with the development of inflammatory reaction of the vascular wall, perivascular edema and ischemic cascade of focal and/or diffuse localization of hypoxic nature of the lesion and, accordingly, have set the goal to study the clinical, pathophysiological and hemodynamic features of chronic migraine in patients.Patients due to intolerance to light and sound became anxious, agitated, aggressive, lost appetite, hyperosmia was observed – they could not stand the smell of food, spices and perfumes, which increased the headache. The attacks led to a sharp decrease in performance and daily activity, which were the main symptom of patients with chronic migraines prevailing group with uncomplicated migraines 2 times (p<0.05), in the majority (53.5%) of patients, it lasted for 3-5 days. After relief of migraine paroxysm-patients noted General lethargy, a feeling of heaviness and fatigue throughout the body, as well as drowsiness.Signs of vertebrobasilar insufficiency were observed in 4 (8.7%) patients, which correlated with the basilar type of chronic migraine, venous dyscirculation mainly along the main artery (a.basilaris) was detected in 28 (60.9%) of the examined patients, and a decrease in blood flow along the anterior cerebellar artery was observed in 2 (4.35%) patients.Vascular dystonia by hypotonic type correlated with a state of lethargy, rapid fatigue, drowsiness and a sharp decrease in performance in the post-seizure period.

• Our results prove the prevalence of organized EEG type in simple migraine and disorganized type in chronic migraine, determining organic brain damage, which can be used to control and select differentiated adequate therapy for various variants of the clinical course of migraine.
• Migraine paroxysms are the background for impaired quality abilities of cerebral vessels, and the frequency and duration of attacks change the normal physiology of blood supply to the brain, being a predictor of acute and chronic brain ischemia, referred as cerebrovascular complications.

Warm Regards,
Alisha
Journal Coordinator
Journal of Translational Neurosciences