In this setting, we wanted to compare and contrast the outcomes of single-fraction and multifraction radiation therapy regimens in a retrospective study. Between 2004 and 2016, we found 87 patients who had an impending or pathologic fracture caused by metastatic disease and underwent neoadjuvant or adjuvant radiation therapy in conjunction with surgical fixation. These patients represented 99 total treatment sites. Patients who intended to receive bimodality therapy were included. Two-sided t tests and Fisher's exact tests were used to compare baseline patient characteristics. The Fine-Gray method was used to calculate the combined incidence of local failure, radiation, and reoperation for competing risks. The Kaplan-Meier method was used to determine the degree of complication-free operation. This is the first study to compare the results of single and multifraction radiation therapy with surgical stabilization of a fracture that is imminent or pathologic. In this setting, there was no difference in outcomes between the single and multifraction regimens. Until prospective validation of these findings, single fraction perioperative radiation therapy may be an effective treatment option for appropriately selected patients. Changes in dynamic contrast-enhanced and diffusion-weighted MRI scans taken before and after single-dose ablative neoadjuvant partial breast irradiation were the focus of our investigation, as was the connection between semiquantitative MRI parameters and radiologic and pathologic responses. From March 2020 to May 2021, at our main campus and regional campuses, we examined the prescriptions for radiation fractionation for all patients with DCIS or ESBC treated with WBI.The electronic medical record was used to extract clinical and demographic information. From licensure data, characteristics of treating physicians were gathered. Factors correlated with ultra-HF-WBI or Gy adoption in five weekly fractions were identified by hierarchical logistic regression models. From August to January, a Veteran's Affairs Medical Center identified prostate cancer patients who received mHFRT treatment. If a patient's prostate PTV was in the highest quartile, they were enrolled in a large prostate planning target volume cohort. Intense late genitourinary and gastrointestinal poisonousness occasions among patients with and without LPTV were looked at. Toxicity effects were estimated using multivariable analyses. Kaplan-Meier analysis was used to estimate patients' overall survival, biochemical recurrence-free survival, and freedom from late GU gastrointestinal toxicity. Patients with muscle invasive bladder cancer receiving definitive RT were eligible. During the maximum transurethral resection of the bladder tumor, TraceIT was injected intravesically around the tumor bed. The primary endpoint was the difference between the standard-of-care pelvic bone anatomy and the radiation treatments' planning margin on daily cone beam computed tomography based on alignment to TraceIT. The best target volume margin for planning was determined using the Van Herk margin formula. The Kaplan-Meier method was used to determine the visibility, recurrence rates, and survival of TraceIT. The Common Terminology Criteria for Adverse Events version was used to measure toxicity. Medical students, excluding those who wish to pursue a career in radiation oncology, have limited exposure to radiation oncology. Thus, RO information in gynecological malignancies might vary among obstetricians and gynecologists, contingent upon their experience and preparing level. Patients' coordination and treatment of gynecological cancers may be enhanced by establishing a program to teach OB&G residents fundamental radiation oncology concepts. At our institution, residents in radiation oncology led OB&G colleagues through a lecture and hands-on training session in two parts. To increase patient care and increase knowledge of radiation treatments, educational sessions geared toward OB&G residents are required. A portion classifier was prepared utilizing RT plans from 86 patients with oropharyngeal disease there were an additional twenty plans in the test set. To determine whether mandible subsites would receive a mean dose, the classifier was trained. For nine patients, the AI predictions were evaluated prospectively and compared to those of a specialist head and neck radiation oncologist. To compare the AI predictions to those of the physician, the positive predictive value, negative predictive value, Pearson correlation coefficient, and Lin concordance correlation coefficient were calculated.

With Regards,
Sara Giselle
Associate Managing Editor
Journal of Stroke Research & Therapy